Abstract: With some technological breakthroughs such as sequencing and microarray in the recent years, genomics, transcriptomics, proteomics, metalomics and phenomics have made a great progress in the world. Theories and technologies of crop breeding have also been revolutionarized considerably. Traditional crop breeding is based on phenotypic selection, which is often called “empirical breeding” with poor predictability, long breeding cycle and low breeding efficiency. Modern crop molecular breeding including marker-assisted breeding, transgenic breeding and molecular design breeding has become an important direction in the field of plant breeding. It is based on the combination of genotypic selection and phenotypic selection and thus target genes/alleles can be directly selected and pyramided. Therefore, the efficiency of molecular breeding can be improved and the breeding duration can be shortened. The paper defines the concept of mole

Key words: Crop, Molecular breeding, Marker-assisted breeding, Transgenic breeding, Molecular design breeding, Strategy